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Senior Citizens & Sex

Sexual Interest Jumps, Memory Does Not for Older Women on Hormone Therapy

Boomer women see 32% increase in sexual thoughts, 44% in sexual interest

Pauline Maki, UIC associate professor of psychiatry - Photo by Kathryn Marchetti UIC Photo ServicesSept. 26, 2007 - A researcher that earlier found additional testosterone decreases verbal memory in older men, has now also determined that hormone therapy in early post-menopause does not improve memory for women. But, it did significantly increase the sexual thoughts and sexual interest for the baby boomer women in the study.

Women treated with hormone therapy reported a 32 percent increase in sexual thoughts and a 44 percent increase in sexual interest when compared to women taking placebo, according to the researchers.

 

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Earlier studies have suggested a possible improvement in verbal memory among older people receiving testosterone or hormone therapy. The findings of this new study were published Sept. 25 in the journal Neurology, the medical journal of the American Academy of Neurology.

"Contrary to what we predicted, hormone therapy did not have a positive affect on memory performance in younger mid-life women," said Pauline Maki, associate professor of psychiatry and psychology at the University of Illinois at Chicago, who led the study.

"If women want to improve hot flashes and night sweats -- the primary reason most women seek menopausal relief -- and they want to improve their sexual focus and interest, then this may be a formulation for them."

Maki and her colleagues enrolled 180 women between the ages of 45 and 55 whose last menstrual cycle was in the past one to three years. The women were randomly assigned to receive either a placebo or a combination of estrogen and progesterone, also known as Prempro, for four months.

The study evaluated memory, attention, cognitive function, emotional status, sexuality and sleep.

No significant changes in cognitive function were identified in the newly menopausal women taking hormone therapy compared to the placebo group.

“These results are similar to previous studies suggesting hormone therapy has minimal effect on a woman’s memory when taken many years after menopause,” said Maki.

“While our results are inconsistent with smaller studies that found improvement in verbal memory for women who only used estrogen, it may be that progesterone modifies the protective effects of estrogen on verbal memory.”

The study also found that women with vasomotor symptoms, such as hot flashes and night sweats, showed a reduction in symptoms and an improvement in overall quality-of-life when taking hormone therapy versus placebo.

The study, which is the largest randomized trial to date examining hormone therapy and memory in midlife women, was stopped early due to declining enrollment that coincided with results of the Women's Health Initiative, which found that the associated health risks of the therapy outweighed the benefits.

The study was funded by Wyeth Pharmaceuticals.

With colleagues at UIC, Maki is also investigating whether botanical therapy, such as black cohosh and red clover, might offer cognitive benefits for mid-life women.

For more information about UIC, visit www.uic.edu

The American Academy of Neurology, an association of more than 20,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and multiple sclerosis.

For more information about the American Academy of Neurology, visit http://www.aan.com.

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