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Senior Citizen Health & Medicine

Cancer Death Risk Continues to Decline Says New Report

Study of 1975-2003 finds the rate of new cancers remains stable

September 7, 2006 - A new report from the nation's leading cancer organizations finds that Americans' risk of dying from cancer continues to drop, while the rate of new cancers remains stable. Certain cancers are increasing - lung cancer rates are up slightly in women; prostate cancer rates have climbed in men. There is good news, too, like cervical cancer incidence and mortality rates decreased for all race/ethnic groups since 1975, and breast cancer stabilized from 2001 through 2003.

 

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Researchers Find Success in Engineering White Blood Cells to Kill Cancer Cells

New method of gene therapy developed at National Cancer Institute

August 31, 2006 – Scientist at the National Cancer Institute are finding success in treating cancer with gene therapy, hoping to find a more effective treatment than chemotherapy or radiation. They have recently found success in melanoma patients by engineering the patient's own white blood cells to recognize and attack the cancer cells. This success, they hope, will lead to treating a number of common cancers. Read more...

PAC-1 Compound Causes Cancer Cells to Self-Destruct

May lead to personalized anti-cancer therapy, scientists say

August 28, 206- A compound called PAC-1 can trick cancer cells into committing suicide, say researcher, who predict this novel technique potentially could lead to an effective method of providing personalized anti-cancer therapy. Read more...

PSA of Prostate Cancer Victims Can Predict How Long They Will Survive

Patients with lower PSA levels 7 months after therapy lived longer

By Nicole Fawcett, University of Michigan Health System

August 25, 2006 - A test used to detect prostate cancer can also help doctors know when treatment is working. A man’s prostate specific antigen, or PSA, level after seven months of hormone therapy for advanced prostate cancer predicted how long he would survive, according to a new multicenter study conducted by the Southwest Oncology Group and led by researchers at the University of Michigan Comprehensive Cancer Center. Read more...


Read more on Health & Medicine

 

The American Cancer Society, Centers for Disease Control and Prevention, National Cancer Institute, and North American Association of Central Cancer Registries collaborate annually to provide U.S. cancer information, this year featuring the first comprehensive compilation of cancer information for U.S. Latinos.

The special section shows that Latinos in the United States are less likely than non-Hispanic whites to develop cancer overall, but are more likely to be diagnosed with advanced cancers.

The long-term trend in overall cancer death rates, declining since the early 1990s, continued through 2003 for all races and both sexes combined. However, female lung cancer incidence rates increased from 1975 to 2003, decelerating since 1991 and breast cancer incidence rates stabilized from 2001 to 2003.

Latinos had lower incidence rates in 1999-2003 for most cancers, but higher rates for stomach, liver, cervix, and myeloma (females) than did non-Latino white populations. Latino children have higher incidence of leukemia, retinoblastoma, osteosarcoma, and germ-cell tumors than do non-Latino white children. For several common cancers, Latinos were less likely than non-Latinos to be diagnosed at localized stages.

Site-Specific Rates by Age

The median age at any cancer diagnosis was the youngest among Latinos at 62 years; while the median age of Non-Hispanic Black patients was 64 years and Non-Hispanic White cases, 68 years, reflecting differences in the age structures of the 3 populations and the specific cancer mix. For female breast, prostate, colon and rectum, lung, and cervical cancer, the Latino cancer incidence rates were the lowest, even within age categories (i.e., 20-39, 40-49, 50-64, 65-74, 75+ years), among the 3 race/ethnic groups, with the exception of cervical cancer in Latinas younger than 65 years (highest rates among all 3 groups) and prostate cancer in Latino men, aged 75 years and older (higher than NHW, but not NHB, men). (A data table is available at: www.seer.gov/report_to_nation/1975_2003/).

Study Highlights

Incidence of Cancer in Men

● Among men, the top 3 incident cancers from 1999 through 2003 continued to be cancers of the prostate, lung, and colon and rectum in all race/ethnic populations.

● Bladder cancer and NHL were the fourth and fifth most common cancers in most race/ethnic populations, with the exception of black and API men.

● Cancers of the kidney and bladder were the fourth and fifth most common sites in black men, and in API men, they were cancers of the liver and stomach.

● Incidence rates declined from 1995 through 2003 for cancers of the lung, stomach, oral cavity, and larynx and increased for thyroid cancer in all race/ethnic populations examined.

● Incidence rates of kidney and liver cancers increased in all race/ethnic populations except API.

● Colon and rectum cancer incidence rates declined in white and non-Hispanic (all races) men, but not in others.

● NHL incidence rates declined in all race/ethnic populations, except non-Hispanic and API.

● Incidence rates were stable for cancers of the prostate and bladder in all race/ethnic populations.

● Three of the top 15 common cancers had different 1995-2003 trends among the race/ethnic groups.
      Pancreatic cancer incidence rates increased in white and non-Hispanic men, but decreased in black men; esophageal cancer incidence rates decreased in Latino (all races), black, and API, but increased in white and non-Hispanic, men. Melanoma increased in non-Hispanic and white men, but decreased in black men.

Age-adjusted Incidence Ratesa for the Top 15 Cancer Sitesb for each Sex by Race/Ethnicity in the Selected Areasc in the United States, 1999-2003

Sex/cancer site

Hispanicd

Non-Hispanic

White

Black

Rank

Rate

Rank

Rate

Rank

Rate

Male

   All Sites

 

444.1

 

565.6

 

650.2

      Prostate

1

141.1

1

157.9

1

246.7

      Lung and Bronchus

2

52.7

2

91.7

2

112.8

      Colon and Rectum

3

52.4

3

64.6

3

71.3

      Urinary Bladder

4

22.2

4

41.8

5

18.5

      Non-Hodgkin Lymphoma

5

19.8

6

23.4

8

16.9

      Kidney and Renal Pelvis

6

16.9

7

18.1

4

18.9

      Stomach

7

16.1

11

9.2

7

17.6

      Liver and Intrahepatic Bile Duct

8

14.8

16

6.5

14

11.2

      Leukemia

9

12.2

8

16.6

13

12.1

      Oral Cavity and Pharynx

10

11.4

9

16.4

6

18.3

      Pancreas

11

11.1

10

12.7

9

16.1

      Larynx

12

6.8

14

7.4

12

12.1

      Myeloma

13

6.5

17

6.3

10

12.8

      Brain and Other Nervous System

14

6.2

12

8.7

15

4.8

      Esophagus

15

5.7

13

8.7

11

12.3

      Melanoma of the Skin

16

4.6

5

24.4

24

1.1

      Testis

17

3.6

15

6.5

23

1.3

Female

   All Sites

 

327.2

 

430.2

 

389.9

      Breast

1

92.6

1

134.4

1

113.4

      Colon and Rectum

2

37.3

3

46.5

2

54.3

      Lung and Bronchus

3

26.7

2

58.7

3

51.3

      Corpus and Uterus, NOS

4

18.7

4

25.0

4

19.9

      Non-Hodgkin Lymphoma

5

14.7

5

16.7

7

11.2

      Cervix Uteri

6

14.7

13

7.9

6

13.2

      Ovary

7

11.4

7

14.6

8

10.2

      Thyroid

8

11.2

8

12.3

13

7.3

      Kidney and Renal Pelvis

9

9.4

12

9.2

9

9.6

      Pancreas

10

9.4

11

9.6

5

13.4

      Stomach

11

9.1

16

4.0

11

9.1

      Leukemia

12

8.4

10

9.8

12

7.8

      Urinary Bladder

13

5.9

9

10.6

14

6.9

      Liver and Intrahepatic Bile Duct

14

5.8

21

2.5

16

3.7

      Brain and Other Nervous System

15

5.0

15

6.2

18

3.6

      Myeloma

16

4.9

17

4.0

10

9.4

      Oral Cavity and Pharynx

17

4.2

14

6.4

15

5.8

      Melanoma of the Skin

18

4.1

6

16.2

28

0.9

   Source: SEER and NPCR areas reported by the North American Association of Central Cancer Registries as meeting high quality standards for 1999-2003.
  a Rates are per 100,000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) and confidence intervals (CI) are 95% for rate ratios (RR); c.f. = compared with.
  b 15 most common cancer in Hispanic males and females.
  c The data from 38 cancer registries [Alabama, Alaska, California, Colorado, Connecticut, Delaware, District Of Columbia, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New York, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Texas, Utah, Washington, West Virginia, Wisconsin] were included covering 82% of U.S., 90% of the Hispanic, 81% of NHW and 79% of NHB populations.
  d NHIA derived Hispanic origin.
  e Rate ratio (RR) is statistically significant (P < 0.05).

● Prostate cancer incidence increased from 1995 through 2003.

 ● Incidence rates for myeloma and leukemia, and cancers of the liver and intrahepatic bile duct (liver), kidney and renal pelvis (kidney), and esophagus have been increasing for 28 years (from 1975 through 2003).

 ● Incidence rates decreased for colon and rectum cancer during 1998-2003,

 ● Cancer incidence rates of the stomach and oral cavity and pharynx (oral cavity) have decreased since 1975 and those of lung and bronchus (lung) since 1982.

 ● Incidence rates were stable in the most recent joinpoint segment through 2003 for the remaining top 15 cancer sites (urinary bladder [bladder], non-Hodgkin lymphoma [NHL], melanoma of the skin [melanoma], and cancers of the pancreas and brain and other nervous system [brain]).

 ● Cancer of the larynx, in the top 15 sites for males in previous years, was replaced by myeloma in this year's ranking.

● Thyroid cancer long-term rates increased in all age groups in both men and women, although the most dramatic increase in men occurred since 1996 among 60-69 year olds (age-specific and long-term trends in males not shown).

Incidence of Cancer in Women

 ● Among women, cancers of the breast, colon and rectum, lung, and uterine corpus continued to be the top 4 incident cancers from 1999 through 2003 in all race/ethnic populations, although the rank order of the top 3 cancers varied.

● The fifth most common cancer was NHL in women of all races and ethnicities, except black and API women. The fifth most common cancer was pancreas in black, and thyroid in API, women.

● Cervical cancer was the only cancer among the top 15 cancers that decreased in women of all races and ethnicities, while cancers of the kidney and thyroid were the only cancers that increased in all female populations.

● Lung cancer incidence rates continued to increase from 1995 through 2003 in non-Hispanic (all races) and white women, but not in women of other races or ethnicity.

● Incidence rates were stable for cancers of the breast and colon and rectum in all race/ethnic populations, except colon and rectal cancer in white women, for which the rates declined from 1995 through 2003.

● Melanoma increased in non-Hispanic, white, and API women. Incidence rates of NHL increased in non-Hispanic and black women, but not in others.

● Ovarian cancer incidence rates declined in women of most races and ethnicity, except black and API women. Stomach cancer incidence rates decreased in women of all races and ethnicities, except Latinas.

● The fixed-interval incidence trends from 1995 to 2003 showed more sex than racial/ethnic differences. The trends in more of the top 15 cancer sites in men were decreasing for each population group than among the top 15 cancer sites in women.

● Rates for NHL, melanoma, leukemia, and cancers of the lung, bladder, and kidney have been increasing for 28 years.

 ● Incidence rates decreased during the most recent segment for cancers of the colon and rectum, corpus and uterus NOS (uterine corpus), ovary, and oral cavity, while stomach and cervix uteri (cervix) cancers have declined since 1975.

 ● Incidence rates for breast cancer stabilized from 2001 through 2003, ending increases begun in the 1980s.

 ● Incidence rates for pancreatic cancer also stabilized from 2000 through 2003, after decreasing for 16 years.

 ● Thyroid cancer incidence rates have increased since 1981; the rate of increase doubling in 1993; and in 2000, doubling again to 9.1% annually through 2003. The long-term rates increased in all age groups in both men and women, although the most dramatic increase in men occurred since 1996 among 60-69 year olds (age-specific and long-term trends in males not shown).

Long-term Mortality Trends for All Cancers Combined and the 15 Most Common Cancer Sites for All Races, 1975-2003

The overall cancer death rates for all race/ethnic populations together increased from 1975 to 1990, were stable from 1990 to 1994, and decreased from 1994 through 2003. The most recent rate declines were greater among men (1.6% per year from 1993 through 2003) than women (0.8% per year from 1992 through 2003).

In the most recent joinpoint segment, death rates decreased for 11 of the 15 most common cancers in men (i.e., lung, prostate, colon and rectum, pancreas, leukemia, NHL, bladder, stomach, brain, myeloma, and oral cavity) and for 10 of the 15 most common cancers in women (i.e., breast, colon and rectum, NHL, leukemia, brain, myeloma, stomach, kidney, cervix, and bladder).

Further, sustained decreases since 1975 have occurred in men for pancreatic cancer and leukemia, and among women, cancers of the colon and rectum, cervix, and bladder.

Death rates increased for esophageal cancer from 1975 through 2003 in men, and for liver cancer at varying rates from 1975 through 2003 in men and 1981 through 2003 in women.

Lung cancer increased from 1975 through 2003 in women; however, the rate of increase decelerated over time.

Death rates were stable in men for kidney cancer and melanoma (both 1991-2003), and in women, for c