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Senior Citizen Health & Medicine

Heart Attack, Bypass Patients Less Fit than Previously Thought

Most women have the aerobic fitness of  a person with life-threatening chronic heart failure

June 7, 2006 – People entering cardiac rehabilitation after a heart attack or bypass surgery are not as fit as has been assumed – especially women. Women typically have the aerobic fitness of a person with life-threatening chronic heart failure. Men in the 2,896-patient study were more aerobically fit than women participants but their average fitness level also proved lower than expected.

 

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Researchers determined the aerobic fitness levels of cardiac patients when they entered an organized rehabilitation program after a recent cardiac event that required hospitalization.  Aerobic fitness is directly related both to how well the heart can pump and to skeletal muscle function, says the study reported in Circulation: Journal of the American Heart Association. 

“I was surprised by several of our results,” said Philip A. Ades, M.D., lead author and professor of medicine and director of Preventive Cardiology and Cardiac Rehabilitation at the University of Vermont College of Medicine in Burlington.   “The biggest surprise was how low the fitness levels were in women.  The average woman in this study fell in the fitness range where cardiologists often consider heart transplantation in heart failure patients.  The take-home message to cardiac surgeons and interventional cardiologists is that the job is only half-done when bypass surgery or coronary stenting is satisfactorily performed.  These patients remain sorely in need of rehabilitation despite optimal in-hospital care.”  

The researchers performed exercise stress testing with expired gas analysis in 815 women and 2,081 men who entered cardiac rehabilitation at the University of Vermont and the Henry Ford Hospital in Detroit from January 1996 to December 2004.   Dr. Steven Keteyian, Ph.D., led the Henry Ford research group.

The patients were hospitalized for heart attack, bypass surgery, angioplasty or chronic angina.   The average age was 61 for males and 62 for females, and most began their rehabilitation within six weeks of leaving the hospital.   The study consisted of Caucasians (71 percent), African Americans (26 percent) and other racial groups (3 percent).

All patients underwent a treadmill test at the start of their rehabilitation program to determine their aerobic fitness, which is done by measuring peak oxygen consumption at their maximum exercise level.

The treadmill test was repeated in 504 of the Vermont patients after they completed 36 rehabilitation sessions over a three-month period.   Key study findings were:

  ● Men had a significantly higher aerobic capacity than women at the start of rehabilitation, even after adjusting for age differences.
  ● Aerobic capacity fell with age in men and women from the third through the eighth decade of life, but the rate of decline was greater in men.
  ● Aerobic capacity varied in men and women according to the reason for hospitalization.   Patients who underwent coronary bypass surgery had the lowest fitness levels, followed by those who had a heart attack or medical treatment for unstable angina.   Finally, those who had a percutaneous (administered or absorbed through the skin) coronary intervention had the highest fitness levels.
  ● Race made no difference in fitness in men or women.
  ● The longer a person remained hospitalized, the lower his or her aerobic capacity.
  ● The 504 patients tested after 36 rehabilitation sessions had an average increase of 17 percent in aerobic capacity. Men had an average increase of 18 percent; women had a 12 percent increase.

“The smaller increase in aerobic capacity in women came as a surprise, and we don’t have a good explanation for it,” Ades said.   “Other studies have found that women are less fit than men when entering rehab but they generally have shown the same relative improvement.”

Study participants probably had better aerobic fitness than patients who failed to enter rehabilitation, he said.   Other studies have found that non-participants tend to be less healthy and less health oriented than those who take up exercise rehabilitation.

Cardiologists use treadmill testing to assess patients' likely longevity and risk of a future heart attack, and to plan a safe and effective exercise program.

Unlike patients in this study who had their oxygen consumption measured, most patients entering cardiac rehabilitation are assessed using estimated metabolic equivalents (METS).   These units are calculated based on the peak miles per hour and percent of elevation of the treadmill attained by patients.

The researchers discovered that calculating METS in this way overestimated the actual METS achieved by men by 30 percent and by women by 23 percent.

Based on their findings, the researcher developed and published revised conversion charts, called nomograms that more accurately indicate the peak METS attained in treadmill tests.

“This study was important because there has been little data on directly measured fitness levels in these patients,” Ades said.   “It also emphasizes the importance of cardiac patients doing organized cardiac rehab, because without it the majority of these patients would remain quite disabled.”

Other co-authors are Patrick D. Savage, M.S.; Clinton A. Brawner, B.S.; Caroline E. Lyon, M.D.; Jonathan K. Ehrman, Ph.D.; Janice Y. Bunn, Ph.D.; and Steven J. Keteyian, Ph.D.

 

 

 

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