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Red Wine Fights Periodontal Disease that Hits Most
Older People
Components modulate tissue damage induced by bacteria
in gum diseases
March 10, 2006 – The latest medical miracle for red
wine is its assist in preventing and treating inflammatory periodontal
disease, which attacks about 65 percent of Americans over age 50,
according to new research. Periodontitis is a progressive infectious
disease affecting the gums and bone that surround and support teeth,
often causing tooth movement and leading to permanent tooth loss. About
65% of adults over 50 are affected by this disease.
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In recent years, the benefits of consuming fresh
fruits and yellow-green vegetables and beverages, particularly green tea
and red wine, have been reported to reduce human cancer incidence and
mortality. The potential health benefits of those products are
attributed to a broad range of compounds called polyphenols. (See
sidebar)
Recent studies have also shown that red wine, and
particularly grape seeds, possesses anti-inflammatory and anti-tumor
activities and prevent heart disease.
Mechanisms by which these phenolic compounds exert
their protective effects include their anti-oxidant properties.
Scientists from Université Laval (Québec, Canada),
reporting today at the 35th Annual Meeting of the American Association
for Dental Research, conducted a study to investigate the role of
polyphenols, including those from red wine, in scavenging free radicals
released by immune cells stimulated with components of bacteria causing
periodontal diseases.
Because free radicals are generated by immune cells
during periodontitis, it is critical to keep them at low levels to
maintain healthy gums.
Their results indicated that red wine polyphenols
significantly modulate several inflammatory components released by
macrophages (a population of host immune cells) in response to bacterial
stimuli.
Specifically, polyphenols efficiently scavenged and
inhibited free-radical generation by host immune cells by controlling
intracellular proteins involved in their release. These anti-oxidant
properties of red wine polyphenols could be useful in the prevention and
treatment of inflammatory periodontal diseases as well as other
disorders involving free radicals.
About this report:
This is a summary of abstract #1080, "Red Wine
Polyphenols Modulate the Oxidative Stress Induced by Periodontopathogens",
by V. Houde, D. Grenier, and F. Chandad, of Université Laval, Québec,
Canada, to be presented at 2 p.m. on Friday, March 10, 2006, in Pacific
Hall of the Walt Disney World Dolphin Hotel, during the 35th Annual
Meeting of the American Association for Dental Research.
Interested readers can refer to an article in the
March, 2006, issue of the Journal of Dental Research, "Anti-inflammatory
Activity of a High-molecular-weight Cranberry Fraction on Macrophages
Stimulated by Lipopolysaccharides from Periodontopathogens", by C. Bodet
et al. of Laval University, Montreal, PQ, Canada (J Dent Res
85[3]:235-239, 2006).
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