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Two Recent Studies

Exercise Proves Valuable in Lowering Risk for Alzheimer’s and Parkinson’s

March 15, 2005 – Two of the diseases most feared by senior citizens – Alzheimer’s and Parkinson’s – may be prevented or slowed by exercise, according to two recent studies. The Alzheimer’s study showed that middle-aged people taking regular exercise at least twice a week could reduce their risk of developing Alzheimer's disease by 50 percent. The Parkinson’s study found that men who exercised regularly and vigorously early in their adult life lowered risk for Parkinson's by as much as 60 percent.

"An active lifestyle, both physical, mental and social, is preventive. It's never too early to start to prevent Alzheimer's disease," said Miia Kivipelto, an Alzheimer's disease specialist at Stockholm's Gerontology Research Centre.

An estimated 12 million people worldwide suffer from Alzheimer's, which is the leading cause of dementia in the elderly. There is no cure for a condition which robs people of their memory and mental ability but drugs have been approved to alleviate symptoms, according to a report by Reuters.

Kivipelto has been involved with other dementia studies indicating the benefits of exercise, healthy diet, and mental activity. Negative factors for Alzheimer’s include high blood pressure, high cholesterol and obesity.

Parkinson's disease is a progressive nervous disease occurring generally after age 50. It destroys brain cells that produce dopamine and is characterized by muscular tremor, slowing of movement, rigidity and postural instability.

Men who were the most physically active at the start of this study cut their risk of developing Parkinson's disease by 50 percent compared to men study participants who were the least physically active. The authors also found that men who reported regularly having engaged in strenuous physical activity in early adult life cut the risk for Parkinson's by 60 percent compared to those who did not.

Among women in the study, strenuous activity in the early adult years was also linked to a lower risk of Parkinson's, but this relationship was not statistically significant, and there was no clear relationship between physical activity later in life and Parkinson's risk.

About the Parkinson’s research, Alberto Ascherio, senior author and associate professor of nutrition and epidemiology at the Harvard School of Public Health, where the study was done, said: "These are intriguing and promising findings that suggest that physical activity may contribute to the prevention of Parkinson's. A protective effect of physical activity has been recently found in an animal model of Parkinson's disease -- this convergence of epidemiological and experimental data is what we are looking for, because consistent results are more likely to reflect biological mechanisms with important clinical implications. Future studies should also address the possibility that physical activity slows the progression of Parkinson's."

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