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Alzheimer's Risk Lowered by Mediterranean Diet in
Study
April 18, 2006 - Americans who ate a Mediterranean
diet--lots of fruits, vegetables, legumes, cereals, some fish and
alcohol, and little dairy and meat--had a reduced risk for Alzheimer's
disease as they aged. These findings are published in the April issue of
Annals of Neurology, a journal published by John Wiley & Sons.
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Alzheimer's & Dementia |
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Experts theorize that diet may play a role in the
development of Alzheimer's disease but epidemiological data on diet and
Alzheimer's is conflicting and while individual foods and nutrients have
been previously studied, general dietary patterns have not. To address
this paucity of data, researchers led by Nikolaos Scarmeas of Columbia
University Medical Center, designed a prospective community-based study
of 2,258 non-demented people in New York City.
The subjects were part of the Washington Heights-Inwood
Columbia Aging project, and for each, the researchers gathered medical
and neurological history, did a standardized physical and neurological
exam, and conducted an in-person interview to assess health and
neuropsychological function. This information was used to diagnose a
presence or absence of dementia. Subjects were reassessed approximately
every 18 months for an average of 4 years.
The researchers also obtained dietary data from
each subject using a semi-quantitative food frequency questionnaire.
They determined a Mediterranean Diet score (0-9) based on a previously
described method. During the course of the study, 262 members of the
study population were diagnosed with Alzheimer's disease.
"Higher adherence to the Mediterranean diet was
associated with significantly lower risk of developing Alzheimer's
disease," the authors report.
For each additional point to Mediterranean diet
scores (indicating increased adherence to the diet), Alzheimer's risk
dropped by 9 to 10 percent.
Compared with the subjects in the least adherent
group that adhered to a Mediterranean diet the least, subjects in the
middle had 15 to 21 percent lower risk of developing Alzheimer's
disease, and those in the highest group had a 39 to 40 percent lower
risk, suggesting a significant dose response effect.
The association remained significant even after
adjusting for potential confounders such as age, gender, ethnicity,
education, caloric intake, BMI, smoking and comorbid conditions.
One possible limitation of this study is the
inaccurate measurement of subjects' diets, though the researchers used a
previously developed and tested dietary assessment, and suggest that
mismeasurements may have actually caused an underestimation of the
association.
Also, disease misclassification is a possible
limitation, though the diagnosis was made by experienced practitioners
and was based on comprehensive assessment and standard criteria. Subtle
changes in dietary habits as a result of early Alzheimer's symptoms,
although another potential limitation, did not seem to be the case since
adherence to the Mediterranean diet was found to be quite stable.
"We conclude that higher adherence to the
Mediterranean diet is associated with a reduction in risk for
Alzheimer's disease," they say.
In addition, they say that the beneficial effects
of the Mediterranean diet for non-neurological conditions have been
previously shown to be generalized to different populations, and that
the current study provided the opportunity to examine the effect of this
diet for a neurological disease in a multiethnic community in the U.S.
About Study:
The study was funded by the National
Institutes of Health's National Institute on Aging.
The article is also to appear online
today at Wiley Interscience (subscription)
click here.
Article: "Mediterranean Diet and
risk of Alzheimer's disease." Scarmeas, Nikolaos; Stern, Yaakov; Tang,
Ming-Xin; Mayeux, Richard; Luchsinger, Jose." Annals of Neurology. April
2006; Published online April 18, 2006.
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