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Wrinkle
Reduction
Reported
in
Clinical
Study
May
14,
2001--Advanced
Tissue
Sciences,
Inc.,
reported
a
reduction
in
facial
wrinkles
in
studies
of
patients
treated
with
a
topical
solution
containing
growth
factors
derived
from
the
company's
human
tissue-engineered
skin.
The
results
of
two
studies
were
described
at
the
Society
of
Investigative
Dermatology
meeting
in
Washington,
DC
on
May
12,
2001.
The
data
suggest
that
such
enriched
solutions
may
be
beneficial
in
the
remodeling
and
regeneration
of
skin,
thereby
reducing
the
appearance
of
visible
wrinkles.
In
the
first
study,
14
patients
with
moderately
wrinkled
skin
used
a
daily
application
of
NouriCel(TM),
an
enriched
nutrient
solution
containing
human
growth
factors
derived
from
Advanced
Tissue
Sciences'
tissue-engineered
skin.
Nine
of
14
patients
(64%)
had
visible
improvements
in
at
least
one
of
four
areas
with
an
average
decrease
in
wrinkle
depth
of
approximately
27%
after
treatment
for
60
days.
An
additional
study
of
16
volunteers
analyzed
biopsies
of
treated
areas
taken
at
the
conclusion
of
a
30-day
NouriCel
trial.
Results
showed
a
50-80%
increase
in
Grenz
zone
collagen
(upper
dermal
collagen)
in
two
of
the
three
formulations
designed
to
optimize
growth
factor
penetration.
Computerized
measurement
of
tissue
density
and
texture
showed
a
42-53%
increase
in
newly
deposited
fine
matrix
fibers.
These
results
are
consistent
with
in
vitro
studies
which
showed
a
statistically
significant
increase
in
fibroblast
and
keratinocyte
proliferation,
collagen
deposition,
and
antioxidant
activity
after
application
of
NouriCel.
``NouriCel
is
part
of
our
effort
to
pursue
more
near-term
opportunities
such
as
the
large
cosmeceuticals
market
for
products
to
treat
aging
skin,''
said
Gail
Naughton,
Ph.D.,
President
of
Advanced
Tissue
Sciences.
NouriCel
is
being
evaluated
as
an
additive
in
cosmetics
including
skin,
hair,
and
nail
products
to
potentially
enhance
aesthetic
outcomes.
NouriCel
is
derived
from
the
nutrient
solutions
used
to
nourish
three-dimensional
human
tissues
in
the
manufacturing
process
developed
by
Advanced
Tissue
Sciences
for
its
line
of
human
tissue-engineered
products.
As
tissues
are
grown,
the
nutrient
solution
collects
soluble
growth
factors,
collagens,
and
antioxidants
produced
by
neonatal
cells.
The
result
is
an
enriched
nutrient
solution
containing
the
complex
array
of
factors
found
in
newborn
skin
but
present
in
lower
amounts
as
skin
matures
or
cells
are
damaged
by
chemicals
and
sunlight
(resulting
in
wrinkles,
sagging,
and
pigmentation
changes).
Advanced
Tissue
Sciences
is
a
tissue
engineering
company
utilizing
its
proprietary
core
technology
to
develop
and
manufacture
human-based
tissue
products
for
tissue
repair
and
transplantation.
For
more
information
on
Advanced
Tissue
Sciences,
visit
the
company
web
site
at:
www.advancedtissue.com.
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