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Aging News & Information

Researchers Learn What It Takes for Men to Reach Age 85 - One Major Surprise

No smoking, excessive drinking, hypertension or obesity but need spouse

 

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November 14, 2006 – Men who want to live to at least age 85 now have a specific strategy that will help them get there – but they need to start at age 54 to exactly fit this model. But give or take a few years probably does not change the formula proposed by this research, which says avoiding smoking, excessive drinking, hypertension and being overweight should just about achieve the goal. One problem, if you are not married you just probably are not going to make it to 85.

 

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The researchers found that high grip strength and avoidance of overweight, hyperglycemia, hypertension, smoking, and excessive alcohol consumption were associated with both overall and exceptional survival.

High education and avoidance of hypertriglyceridemia (elevated triglyceride level) were associated with exceptional survival, but lack of a marital partner was associated with death before age 85 years.

Bradley J. Willcox, M.D., of the Pacific Health Research Institute and Kuakini Medical Center in Honolulu, presented the findings of the study today at a Journal of the American Medical Associatin media briefing on men’s health in New York. The study will be in the November 15 issue of JAMA, a theme issue on men’s health.

Background

Persons alive at age 85 years or older are the fastest-growing age group in most industrialized countries and are among the largest consumers of health care resources.

Identifying strategies for remaining healthy, vigorous, and disability-free at older ages has become a major priority, according to background information in the article. Studies with substantial numbers of long-lived participants and characteristics associated with longer survival are rare but essential to identify risk factors for health and survival at older ages.

About the study

Dr. Willcox and colleagues examined potential biological, lifestyle, and sociodemographic risk factors present at middle-age to identify risk factors for healthy survival. The study included 5,820 Japanese-American middle-aged men (average age, 54) in the Kuakini Honolulu Heart Program/Honolulu Asia Aging Study.

The participants were free of illness and functional impairments and were followed for up to 40 years (1965-2005) to assess overall and exceptional survival. Exceptional survival was defined as survival to a specified age (75, 80, 85, or 90 years) without incidence of 6 major chronic diseases and without physical and cognitive impairment.

The diseases were coronary heart disease, stroke, cancer (excluding nonmelanoma skin cancer), chronic obstructive pulmonary disease, Parkinson disease, and treated diabetes.

Of the 5,820 original participants, 2,451 participants (42 percent) survived to age 85 years and 655 participants (11 percent) met the criteria for exceptional survival to age 85 years.

Factors associated with both overall and exceptional survival included a high grip strength and avoidance of overweight, hyperglycemia, hypertension, smoking, and excessive alcohol consumption. In addition, high education and avoidance of hypertriglyceridemia (elevated triglyceride level) were associated with exceptional survival, and lack of a spouse was associated with death before age 85 years.

Risk factor models based on cumulative risk factors (survival risk score) suggest that the probability of survival to age 85 years is as high as 69 percent with no risk factors and as low as 22 percent with 6 or more risk factors. The probability of exceptional (healthy) survival to age 85 years was 55 percent with no risk factors but decreased to 9 percent with 6 or more risk factors

“Anthropometric [measurement and study of the human body and its capacities] measures from this study, such as grip strength, suggest that it is important to be physically robust in midlife. This is consistent with theories of aging that suggest that better-built organisms last longer and that physiological reserve is an important determinant of survival,” the authors write. This may also be a marker of physical fitness.

“In summary, we have identified several potentially important risk factors for healthy survival in a large group of middle-aged men. These risk factors can be easily measured in clinical settings and are, for the most part, modifiable. This study suggests that common approaches that target multiple risk factors simultaneously, such as avoidance of smoking or hypertension, and approaches that enhance insulin sensitivity, such as maintaining a lean body weight, may improve the probability of better health at older ages. This may be especially important for men, few of whom survive to oldest-old age,” the researchers conclude.

Editor's Note: This study was supported by a contract from the National Heart, Lung, and Blood Institute, and contract and grants (including Hawaii Lifespan Study) from the National Institute on Aging, and a grant from the Hawaii Community Foundation.

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