Nursing Home Dementia Patients Three Times as Likely to Fall if on Antidepressants
Selective serotonin reuptake inhibitors (SSRIs) appear to cause risk to rise with higher doses
Jan. 19, 2012 - Nursing home residents with dementia who use average doses of selective serotonin reuptake inhibitors (SSRIs)
are three times more likely to have an injurious fall than similar people who don’t use these drugs.
The association can be seen in people who
use low doses of SSRIs and the risk increases as people take higher doses. The results are published in the British Journal of Clinical
Pharmacology.
Many nursing home residents with dementia suffer from depression, and are therefore treated with antidepressants.
Selective serotonin reuptake inhibitors (SSRIs) are generally considered the treatment of choice.
“Our study also discovered that the risk of an injurious fall increased even more if the residents were also given
hypnotic or sedative drugs as sleeping pills,” said lead author Carolyn Shanty Sterke, who works in the Section of Geriatric Medicine at
Erasmus University Medical Center, Rotterdam, The Netherlands.
Falls are a major health problem in nursing home residents with dementia. In nursing homes one-third of all falls result
in an injury. “Physicians should be cautious in prescribing SSRIs to older people with dementia, even at low doses,” says Sterke.
Sterke carried out this research by recording the daily drug use and daily falls in 248 nursing home residents with
dementia from 1 January 2006 until 1 January 2008.
Data about the residents’ day-by day drug use came from a prescription database, and information on falls and subsequent
injuries came from a standardised incident report system. In total, she had collected a dataset of 85,074 person-days.
The mean age of the participants was 82 years, and the prescription records showed that antidepressants had been used on
13,729 (16.1%) days, with SSRIs being used on 11,105 of these days.
Highlights
● The incident reports showed that 152 of the 248 residents (61.5%) sustained 683 falls.
● This corresponds to a fall incidence of 2.9 falls per person-year.
● Thirty-eight residents had a single fall, but 114 fell frequently.
● Two hundred twenty falls resulted in injury or death.
● Of these 10 were hip fractures, 11 were other fractures and 198 were injuries such as grazes, open wounds, sprains,
bruises, and swellings.
● One person died after falling.
The risk of having an injurious fall increased threefold for residents taking SSRIs, from an absolute daily risk of 0.09%
for a female aged 80 not taking an SSRI, to 0.28% for a female aged 80 taking one defined daily dose of SSRIs. Similar increases in absolute
daily risk were found for both men and women, for different ages.
“Staff in residential homes are always concerned about reducing the chance of people falling and I think we should
consider developing new treatment protocols that take into account the increased risk of falling that occurs when you give people SSRIs,” says
Sterke.
Links to Archived Reports on
Senior Citizens and Risk of Falls
One-point decrease on social activity scale was
equivalent to being approximately five years older at the start of the
study - risk of death, disability jump
Jan. 19, 2012 - Nursing home residents with dementia who use average doses of selective serotonin reuptake inhibitors (SSRIs)
are three times more likely to have an injurious fall than similar people who don’t use these drugs. 
