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Why Does Hair Turn Gray? Communications Problem Between Hair Follicle and Stem Cells

Findings also offer insight into human tissue regeneration

June 14, 2011 – Recent research may hold the answer to a question that has perplexed millions of senior citizens: why does hair turn gray? The new study has shows that Wnt signaling - already known to control many biological processes in human development - between hair follicles and melanocyte stem cells can dictate hair pigmentation.

“We have known for decades that hair follicle stem cells and pigment-producing melanocycte cells collaborate to produce colored hair, but the underlying reasons were unknown,” said Mayumi Ito, PhD, assistant professor in the Ronald O. Pereleman Department of Dermatology at NYU Langone Medical Center and leader of the study.


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“We discovered Wnt signaling is essential for coordinated actions of these two stem cell lineages and critical for hair pigmentation.”

The Wnt signaling pathway is a network of proteins best known for their roles in embryogenesis (the process by which the embryo is formed and develops until it is a fetus) and cancer, but also involved in normal physiological processes in adult animals, according to Wikipedia.

The study, published in the June 11, 2011 issue of the journal Cell, suggests the manipulation of Wnt signaling may be a novel strategy for targeting pigmentation such as graying hair.

The research study also illustrates a model for tissue regeneration.

“The human body has many types of stem cells that have the potential to regenerate other organs,” said Dr. Ito.

“The methods behind communication between stem cells of hair and color during hair replacement may give us important clues to regenerate complex organs containing many different types of cells.”

Using genetic mouse models, researchers were able to examine how Wnt signaling pathways enabled both hair follicle stem cells and melanocyte stem cells to work together to generate hair growth and produce hair color.

Research also showed the depletion (or inhibition, or abnormal) Wnt signaling in hair follicle stem cells not only inhibits hair re-growth but also prevents melanocytes stem cell activation required for producing hair color.

The lack of Wnt activation in melanocyte stem cells leads to depigmented or gray hair.

The study raises the possibility that Wnt signaling is a key pathway for the regulation of melanocyte stem cells and shows how melanocyte behavior is associated with hair regeneration. This insight provides further understanding of diseases in which melanocytes are either appropriately lost such as hair graying or undergo uncontrolled cell growth as in melanoma.

>> Wnt Signaling - Wikipedia

>> The Wnt Home Page – Stanford University

>> Wnt signaling: a common theme in animaldevelopment

>> NYU Langone Medical Center

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